Early detection of colorectal adenocarcinoma using antibodies against minichromosome maintenance (MCM) proteins.
This translational work was carried out as a collaborative venture between the Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge and the Colorectal Unit, Department of General Surgery, Addenbrooke's Hospital, Cambridge.
I aimed to develop a novel, non-invasive method for the detection of colorectal cancer in stool. I initially designed a cell line model to optimise retrieval of neoplastic colonocytes from the stool surface and subsequent MCM protein detection. Cell yield was significantly increased if the stool was kept on ice, and addition of a mucolytic agent to the suspending solution significantly increased cell yield.
These findings were taken forward into a clinical evaluation study, which had ethical approval. I recruited 52 subjects with colorectal cancer and 35 control subjects. Using three different techniques for colonocyte retrieval, MCM-positive cells, identified by immunocytochemistry, were retrieved from the stool of 49 of 52 subjects with colorectal cancer and none of 35 controls.
In an attempt to identify potential sources of false-positive results, I carried out an immunohistochemical assessment of MCM protein expression in inflammatory bowel disease. This demonstrated aberrant expression of MCMs in the superficial aspect of colonic glands in active ulcerative colitis and active Crohn's disease.
The work identified a novel, stool-based method for colorectal cancer detection, and resulted in the award of a Master of Surgery degree from the University of Cambridge, peer-review publications (including first author papers in high impact factor journals such as the Lancet and Nature Reviews Cancer) and several prizes and awards (including the Patey Prize and John of Arderne Medal). It also highlighted a potential method for stool-based monitoring of inflammatory bowel disease activity, and provides avenues for future research in these areas. Further funding was subsequently awarded to allow the appointment of a research fellow to continue with this work.
Davies R J.
Commentary on: Risk factors predictive of severe diverticular hemorrhage. International Journal of Surgery 2011; 9: 83-85 (invited commentary). International Journal of Surgery 2011; 9: 353-354
Ali J, Rajaratnam S, Davies R J.
"Omental wrap": A simple technique to close the mesenteric defect after laparoscopic right hemicolectomy. Annals of The Royal College of Surgeon of England 2011; 93: 418
Noorani A, Rabey N, Walsh S R, Davies R J.
Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidine-iodine in clean, contaminated surgery British Journal of Surgery 2010; 97: 1614-1620
Courtney E, Brennan M, Noble-Jamieson G, Heuschkel R, Davies R J
Laparoscopic adult colorectal surgeon and adolescents with inflammatory bowel disease: a safe combination? International Journal of Colorectal Disease 2011;26:357-360
Wiles A P, Cameron E A B, Lomas D J, Davies R J, Save V.
An unusual cause of anaemia. Gut 2010;59:1139,1338
Marshall A E, Rushbrook S M, Vowler S L, Palmer C R, Davies R J, Gibbs P, Davies S E, Coleman N, Alexander G J M.
Tumour recurrence following liver transplantation for hepatocellular carcinoma: Role of tumor proliferation status. Liver Transplantation 2010; 16: 279-288
Alvi A, Wood L, Davies R J.
A selective policy ensures safe integration of laparoscopic colorectal resection into the practice of a newly appointed consultant surgeon. Open Colorectal Cancer Journal 2009; 2: 7-10
Davies R J.
UK Travelling Fellow Report 2008 Colonews, Autumn 2008: 11-12
Swett Cosentino J, Davies R J, McLeod R S, Cohen Z.
Lymphoma following ileal pouch-anal anastomosis. Canadian Journal of Surgery 2009; 52: 123-126
Scarpini C, White V, Muralidhar B, Patterson A, Hickey N, Singh N, Mullerat J, Winslet M, Davies R J, Phillips M, Stacey P, Laskey R A, Miller R, Nathan M, Coleman N.
Improved screening for anal neoplasia by immunocytochemical detection of minichromosome maintenance proteins. Cancer Epidemiology, Biomarkers and Prevention 2008; 17: 2855-2864
Davies R J, O'Connor B I, Victor C, MacRae H M, Cohen Z, McLeod R S.
A prospective evaluation of sexual function and quality of life following ileal pouch-anal anastomosis. Diseases of the Colon and Rectum 2008; 51: 1032-1035
Davies R J.
Haemorrhoids American Family Physician 2006; 74: 1168-1172
Davies R J.
Haemorrhoids BMJ Clinical Evidence Concise 2006; 16: 211-214
Davies R J.
Haemorrhoids. Clinical Evidence 2006; 15: 711-724
Chatrath P, Scott I S, Morris L S, Davies R J, Bird K, Vowler S L, Coleman N.
Immunohistochemical estimation of cell cycle phase in laryngeal neoplasia. British Journal of Cancer 2006; 95: 314-321
Davies R J.
Haemorrhoids. Clinical Evidence Concise 2006; 15: 180-183
Scott I S, Odell E, Chatrath P, Morris L S, Davies R J, Vowler S L, Laskey R A, Coleman N.
A minimally invasive immunocytochemical approach to early detection of oral malignancy and dysplasia. British Journal of Cancer 2006; 94: 1170-1175
Harris M R E, Davies R J, Brown S, Jones S M, Eyers P S, Chester J F.
Surgical treatment of varicose veins: effect of rationing. Annals of The Royal College of Surgeons of England 2006; 88: 37-39
Davies R J, Miller R, Coleman N.
Screening for colorectal cancer using stool. Discovery Medicine 2005; 5: 175-179
Davies R J, Barros D'Sa I, Lucarotti M E, Fowler A L, Tottle A, Birch P, Cook T A.
Bowel function following insertion of self-expanding metallic stents for palliation of colorectal cancer. Colorectal Disease 2005; 7: 251-253
Davies R J, Miller R, Coleman N.
Colorectal cancer screening: prospects for molecular stool analysis. Nature Reviews Cancer 2005; 5: 199-209
Davies R J, Collins C D, Vickery C J, Eyre-Brook I, Welbourn R.
Reduction in the proportion of patients with colorectal cancer presenting as an emergency following the introduction of fast-track flexible sigmoidoscopy: a three-year prospective observational study. Colorectal Disease 2004; 6: 265-267
Davies R J, Pryce Lewis J, Welbourn R.
Higher surgical training in laparoscopic surgery in the south western deanery: results of a regional survey. Annals of The Royal College of Surgeons of England (Suppl) 2004; 86: 48-49
Davies R J, Scott I S, Morris L S, Rushbrook S M, Bird K, Vowler S, Arends M J, Miller R, Coleman N.
Minichromosome maintenance protein 2 expression in active inflammatory bowel disease. Colorectal Disease 2004; 6: 103-110
Scott I S, Morris L S, Bird K, Davies R J, Vowler S L, Rushbrook S M, Marshall A E, Laskey R A, Miller R, Arends M J, Coleman N.
A novel immunohistochemical method to estimate cell cycle phase distribution in archival tissue: implications for the prediction of outcome in colorectal cancer. Journal of Pathology 2003; 201: 187-197
Chatrath P, Scott I S, Morris L S, Davies R J, Rushbrook S M, Bird K, Vowler S L, Grant J W, Saeed I T, Howard D, Laskey R A, Coleman N.
Aberrant expression of minichromosome maintenance protein-2 and Ki67 in laryngeal squamous epithelial lesions. British Journal of Cancer 2003; 89: 1048-1054
Davies R J.
Early detection of colorectal adenocarcinoma using antibodies against minichromosome maintenance proteins. MChir thesis, University of Cambridge; 2003
Davies R J, Freeman A, Morris L, Bingham S, Dilworth S, Scott I S, Laskey R, Miller R, Coleman N.
Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool. Lancet 2002; 359: 1917-1919
Davies R J, Ewings P, Welbourn R, Collins C, Kennedy R, Royle C.
A prospective study to assess the implementation of a fast-track system to meet the two-week target for colorectal cancer in Somerset. Colorectal Disease 2002; 4: 28-30
Bury A, Underhill A E, Burke K, Fleming R P E, Davies R J, Gomm PS.
Metal complexes of anti-inflammatory drugs. Inorganica Chimica Acta 1988; 152: 171-175
PUBLISHED BOOK CHAPTER
Davies R J, Miller R.
What is the role of prophylactic surgery in the prevention of colorectal cancer?
In: Evidence Based Oncology (eds Williams C, Bramwell V, Bonfill X, Cuzick J, Forbes J, Grant R, Guthrie D, Mason M, Simmonds P, Singh A D, Weston R, Williams H) 2003. BMJ Publishing Group, London. p.104-109
PUBLISHED CORRESPONDENCE
Walsh S, Noorani A, Rabey N, Davies R J.
Authors reply: Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidine-iodine in clean, contaminated surgery. (British Journal of Surgery 2010; 97: 1614-1620) British Journal of Surgery 2011; 98: 462
Davies R J.
A systematic review of the impact of volume of surgery and specialization on patient outcome (British Journal of Surgery 2007; 94: 145-161). British Journal of Surgery 2007; 94: 645
Davies R J.
Shift work and surgical training: an observational study in one district general hospital (Annals of The Royal College of Surgeons of England (Suppl) 2003; 85: 196-199). Annals of The Royal College of Surgeons of England (Suppl) 2004; 86: 85
Davies R J.
Randomized clinical trial comparing consultant-led or open access investigation for large bowel symptoms (British Journal of Surgery 2003; 90: 941-947). British Journal of Surgery 2003; 90: 1453
Surgical mangement of Diverticulitis.
M25 Course, Pelican Centre, Basingstoke. April 2010
Sigmoid Volvulus.
M25 Course, Pelican Centre, Basingstoke. April 2010
Modern Management of Haemorrhoids.
Association of Coloproctology of Great Britain and Ireland East Anglian Annual Chapter Meeting, Cambridge. February 2010
Laparoscopic surgery for inflammatory bowel disease.
East Anglian Inflammatory Bowel Disease Specialist Nurses Forum, Newmarket.
November 2009
Surgery for adolescents with inflammatory bowel disease- recent advances.
Children with Crohn's and Colitis Annual Meeting, UCL Institute of Child Health, Great Ormond Street Hospital, London. June 2009
Laparoscopic Surgery and Inflammatory Bowel Disease.
South West Gastroenterology Society Annual Scientific Meeting, Newquay. June 2009
ACPGBI/RSM Section of Coloproctology Travelling Fellow 2008 Report.
East Anglian Chapter Association of Coloproctology of Great Britain and Ireland Annual Meeting, Norwich. November 2008
Laparoscopic Surgery in Inflammatory Bowel Disease- State of the Art (Keynote Lecture).
East of England Paediatric Gastroenterology Study Day, Newmarket. September 2008
Molecular stool analysis: The future of screening for colorectal cancer?
American Society of Colon and Rectal Surgeons Tripartite Meeting, Boston, USA. June 2008
The laparoscopic fellowship experience: Time well spent?
Symposium on training in laparoscopic colorectal surgery, Royal Society of Medicine Section of Coloproctology, London. February 2008
Laparoscopic surgery for colorectal cancer.
GI Cancer Forum, Cambridge Research Institute, Cambridge. February 2008
A fellowship in laparoscopic and open colorectal surgery at the University of Toronto, Canada.
Association of Laparoscopic Surgeons of Great Britain and Ireland Annual Meeting, Newcastle. November 2007
Laparoscopic surgery for inflammatory bowel disease.
East Anglian Gut Club Annual Meeting, Newmarket. November 2007
Ileal pouch-anal anastomosis.
Ostomy Preceptorship Course, St Michaels's Hospital, Toronto, Canada. February 2007
Colorectal cancer screening: prospects for molecular stool analysis.
Association of Coloproctology of Hungary Annual Meeting, Hajduszoboszlo, Hungary. April 2005
A non-invasive, stool-based test for the detection of colorectal cancer using antibodies directed against DNA replication protein Mcm2.
Royal Society of Medicine Section of Coloproctology, Overseas Meeting, Bruges, Belgium. May 2003
Non-invasive molecular detection of colorectal cancer.
St. George's Gastroenterology Teaching Day, St. George's Hospital, London. February 2003
Sifting stool for Mcm2.
The Ninth Royal Free Hospital Combined Medical and Surgical G.I. Masterclass - The Colon Masterclass. Royal Free Hospital, London. January 2003
A novel, stool-based screening test for colorectal cancer using antibodies directed against DNA replication protein Mcm2.
Society of University Surgeons Annual Meeting, Honolulu, Hawaii, USA. February 2002
PERSONALLY DELIVERED ORAL PRESENTATIONS TO LEARNED SOCIETIES
Davies R J, O'Connor B I, Victor C, MacRae H M, Cohen Z, McLeod R S.
A prospective evaluation of sexual function and quality of life in males and females following ileal pouch-anal anastomosis.
European Society of Coloproctology Annual Meeting, Portomaso, Malta, September 2007 Colorectal Disease 2007; 9 (Suppl 3): 3
Davies R J, O'Connor B I, Victor C, MacRae H M, Cohen Z, McLeod R S.
A prospective evaluation of sexual function and quality of life in males and females following ileal pouch-anal anastomosis.
Association of Coloproctology of Great Britain and Ireland Annual Meeting, Glasgow. July 2007 Colorectal Disease 2007; 9 (Suppl 1): 20
Davies R J, O'Connor B I, Victor C, MacRae H M, Cohen Z, McLeod R S.
A prospective evaluation of sexual function and quality of life in males and females following ileal pouch-anal anastomosis.
University of Toronto Annual Surgical Assembly, Toronto, Canada. June 2007
Davies R J, Parsons B, Corr C, Durdey P, Sylvester P A, Virjee J, Callaway M.
How should we investigate lower gastrointestinal tract bleeding?
Royal Society of Medicine Section of Coloproctology, Annual Overseas Meeting, Prague, Czech Republic. June 2006
Davies R J, Barros D'Sa I, Lucarotti M E, Fowler A L, Birch P, Tottle A, Cook T A.
Bowel function and survival following insertion of self-expanding metallic stents (SEMS) for palliation of colorectal cancer.
Surgical Club of South West England Meeting (Trainees Prize Winning Paper), Cheltenham Racecourse, Cheltenham. October 2004
Davies R J, Barros D'Sa I, Lucarotti M E, Fowler A L, Birch P, Tottle A, Cook T A.
Bowel function and survival following insertion of expandable colonic stents for colorectal cancer.
Association of Coloproctology of Great Britain and Ireland Annual Meeting, Birmingham. June 2004 Colorectal Disease 2004; 6 (Suppl 1): 20
Davies R J, Barros D'Sa I, Lucarotti M E, Fowler A L, Birch P, Tottle A, Cook T A.
Bowel function and survival following insertion of expandable colonic stents for colorectal cancer.
Royal Society of Medicine Section of Coloproctology, Overseas Meeting, Granada, Spain. May 2004
Davies R J, Coleman N, Miller R.
Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool.
Surgical Club of South West England Meeting (John Farndon Prize Winning Paper), Bristol Royal Infirmary, Bristol. October 2003
Davies R J, Collins C D, Vickery C J, Eyre-Brook I, Welbourn R.
Reduction in the proportion of patients with colorectal cancer presenting as an emergency following the introduction of fast-track flexible sigmoidoscopy: results of a three-year prospective observational study.
Surgical Club of South West England Meeting (Trainees Prize Session), Bristol Royal Infirmary, Bristol. October 2003
Davies R J, Scott I S, Morris L S, Coleman N, Miller R.
Minichromosome maintenance protein 2 expression in inflammatory bowel disease: a potential novel marker of disease activity.
Association of Coloproctology of Great Britain and Ireland Annual Meeting (BJS Prize and Colon & Rectal Disease Research Foundation Prize Session), Edinburgh. July 2003 Colorectal Disease 2003; 5 (Suppl 1): 9
Davies R J, Collins C D, Eyre-Brook I, Vickery C J, Welbourn R.
Reduction in the proportion of patients with colorectal cancer presenting as an emergency following the introduction of the two-week target: results of a three-year prospective observational study.
Association of Coloproctology of Great Britain and Ireland Annual Meeting, Edinburgh. July 2003 Colorectal Disease 2003; 5 (Suppl 1): 20
Davies R J, Scott I S, Morris L S, Coleman N, Miller R.
Cell cycle marker expression in inflammatory bowel disease: the potential role of minichromosome maintenance protein 2 as a novel marker of disease activity.
Association of Surgeons of Great Britain and Ireland Annual Meeting (Moynihan Prize Plenary Session), Manchester. May 2003 British Journal of Surgery 2003; 90 (Suppl 1): 31
Davies R J, Scott I S, Bingham S, Coleman N, Miller R.
A novel method for the detection of colorectal cancer in stool.
Tripartite 2002 Colorectal Meeting, Melbourne, Australia. October 2002 Diseases of the Colon and Rectum 2002; 45: A13
Davies R J, Morris L S, Bingham S, Scott I S, Coleman N, Miller R.
A novel method for the detection of colorectal cancer in stool: results of a cell line model and clinical evaluation study.
Association of Coloproctology of Great Britain and Ireland Annual Meeting, Manchester. July 2002 Colorectal Disease 2002; 4 (Suppl 1): 11-12
Davies R J, Bandaletova T, Bailey N, Morris L S, Bingham S, Scott I S, Coleman N, Miller R.
A novel, non-invasive test for the detection of colorectal cancer in stool.
Digestive Diseases Week, American Gastroenterology Association, San Francisco, USA. May 2002 Gastroenterology 2002; 122: A39-40
Davies RJ, Morris L, Bailey N, Bingham S, Coleman N, Miller R.
A novel, stool-based screening test for colorectal cancer using antibodies directed against DNA replication protein Mcm2. (Patey Prize Winning Paper)
Society of Academic and Research Surgery, Inaugural Meeting, London. January 2002 British Journal of Surgery 2002; 89: 643
Davies R J, Morris L, Bingham S, Coleman N, Miller R.
A non-invasive, stool-based test for the detection of colorectal cancer using antibodies directed against DNA replication protein Mcm2. (John of Arderne Medal Winning Paper)
Royal Society of Medicine Section of Coloproctology, Short Papers Meeting, London. November 2001 Colorectal Disease 2002; 4: 147
Davies R J, Welbourn R, Collins C, Kennedy R, Royle C.
Meeting the two-week target for colorectal cancer in Somerset: a prospective study.
Association of Surgeons of Great Britain and Ireland Annual Meeting, Birmingham. May 2001 British Journal of Surgery 2001; 88 (Suppl 1): 42
Davies R J, Coleman N, Miller R.
Development of a stool-based screening test for colorectal cancer using antibodies directed against minichromosome maintenance proteins. (Registrar Prize Winning Paper)
East Anglian Surgical Club Meeting, Peterborough. May 2001
Davies R J, Welbourn R, Collins C, Kennedy R, Royle C.
A prospective study to assess the implementation of a fast-track system to meet the two-week target for colorectal cancer.
Surgical Club of South West England Meeting (Registrar Prize Session), Yeovil. November 2000
Davies R J, Vickery C, Anthony A, Alderson D.
Familial oesophageal stromal tumours presenting as achalasia.
British Society of Gastroenterology (South West Division), Newquay. June 1999.
Davies R J, Longman R J, Crowther M, Durdey P, Thomas M G.
Auditing the pre-operative assessment of colorectal cancer patients: are we achieving the Guidelines?
Audit, epidemiology or outcome? The Royal College of Surgeons of England, London. June 1998. Annals of The Royal College of Surgeons of England 1998; 80: 443
POSTER AND OTHER ORAL PRESENTATIONS TO LEARNED SOCIETIES
Noorani A, Durrani A, Walsh S R, Davies R J.
Sentinel lymph node biopsy for staging of squamous call carcinoma of the anus: A systematic review
European Society of Coloproctology Annual Meeting, Copenhagen, Denmark. September 2011 Colorectal Disease 2011 (in press)
Page A, Khan A, Rajaratnam S, Carroll N, Hall NR, Davies R J
Is follow-up endoscopy necessary after successful medical treatment of CT-proven acute diverticulitis?
Tripartite Colorectal Meeting, Cairns, Australia. July 2011 Colorectal Disease 2011 (in press)
Ariyaratnam J, Fearnhead NS, Rajaratnam S, Koo B, Durrani A, Davies R J
CT angiography is a useful modality for planning flap reconstruction after radical pelvic surgery.
Tripartite Colorectal Meeting, Cairns, Australia. July 2011 Colorectal Disease 2011 (in press)
Ali J, Rajaratnam S, Dennis R, Davies R J.
A simple technique to close the mesenteric defect after laparoscopic right hemicolectomy.
Tripartite Colorectal Meeting, Cairns, Australia. July 2011 Colorectal Disease 2011 (in press)
Ariyaratnam J, Davies R J, Fearnhead NS, Koo B, Durrani A
CT angiography is a useful modality for planning flap reconstruction after radical pelvic surgery.
British Association of Plastic, Reconstructive and Aesthetic Surgeons Annual Meeting, Oxford. July 2011
Page A, Khan A, Rajaratnam S, Carroll N, Hall NR, Davies R J
Is follow-up endoscopy necessary after successful medical treatment of CT-proven acute diverticulitis?
Association of Coloproctology of Great Britain and Ireland Annual Meeting, Birmingham, June 2011 Colorectal Disease 2011; 13 (Suppl 4): 17
Identifying and characterising quiescent stem cell populations in intestinal tumours
Buczacki S, Davies R J, Winton D.
Association of Coloproctology of Great Britain and Ireland East Anglian Annual Chapter Meeting, Cambridge. May 2011 (Trainees Prize Winning Paper)
Page A, Khan A, Rajaratnam S, Carroll N, Hall NR, Davies R J
Is follow-up endoscopy necessary after successful medical treatment of CT-proven acute diverticulitis?
British Society of Gastroenterology Annual Meeting, Birmingham, March 2011 Gut 2011; 60 (Suppl 1): A72
Noorani A, Rabey N, Walsh S, Davies R J.
Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidine-iodine in clean, contaminated surgery Norman Tanner Prize Meeting, Royal Society of Medicine Section of Surgery, London. December 2010
Noorani A, Rabey N, Walsh S, Davies R J.
Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidine-iodine in clean, contaminated surgery European Colorectal Congress, St Gallen, Switzerland, December 2010
Noorani A, Rabey N, Walsh S, Davies R J.
Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidine-iodine in clean, contaminated surgery East Anglian Surgical Club Annual Meeting, Norwich. October 2010
Kandaswamy K, Durrani A, Malata C Wilson C, Fearnhead N S, Davies R J.
Multidisciplinary salvage surgery for anal cancer- clear margins come at a cost.
European Society of Coloproctology Annual Meeting, Sorrento, Italy. September 2010 Colorectal Disease 2010; 12 (Suppl 3): 42
Noorani A, Rabey N, Walsh S, Davies R J.
Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidine-iodine in clean, contaminated surgery
European Society of Coloproctology Annual Meeting, Sorrento, Italy. September 2010 Colorectal Disease 2010; 12 (Suppl 3): 36
Kandaswamy K, Durrani A, Malata C Wilson C, Fearnhead N S, Davies R J.
Multidisciplinary salvage surgery for anal cancer- clear margins come at a cost.
Association of Coloproctology of Great Britain and Ireland Annual Meeting, Bournemouth. June 2010 Colorectal Disease 2010; 12 (Suppl 1): 28
Courtney E, Brennan M, Noble-Jamieson G, Heuschkel R, Davies R J.
Laparoscopic adult colorectal surgeon and adolescents with inflammatory bowel disease: a safe combination?
Association of Coloproctology of Great Britain and Ireland Annual Meeting, Bournemouth. June 2010 Colorectal Disease 2010; 12 (Suppl 1): 30
Kandaswamy K, Malata C, Wilson C, Fearnhead N S, Davies R J.
Multidisciplinary salvage surgery for anal cancer- clear margins come at a cost.
Association of Surgeon of Great Britain and Ireland Annual Meeting, Liverpool. April 2010 (Poster of Distinction) British Journal of Surgery 2010; 97 (Suppl 2): 60
Kandaswamy K, Malata M, Durrani A, Wilson C, Fearnhead N S, Davies R J.
Multidisciplinary salvage surgery for anal cancer- clear margins come at a cost.
Association of Coloproctology of Great Britain and Ireland East Anglian Annual Chapter Meeting, Cambridge. February 2010.
Courtney E, Brennan M, Noble-Jamieson G, Heuschkel R, Davies R J.
Laparoscopic adult colorectal surgeon and adolescents with inflammatory bowel disease: a safe combination?
Association of Laparoscopic Surgeons of Great Britain and Ireland Annual Meeting, Tonbridge. November 2009
Younis F, Stabler A, Courtney E, Davies R J.
Fellowship training in a specialist inflammatory bowel disease unit facilitates good short-term outcomes in the development of a laproscopic service.
Association of Laparoscopic Surgeons of Great Britain and Ireland Annual Meeting, Tonbridge. November 2009
McGrath D, Shaik R, Wood L, Hall N R, Davies R J
Right versus left laparoscopic colorectal resections length of stay- a counter intuitive finding.
European Society of Coloproctology Annual Meeting, Prague, Czech Republic. September 2009 Colorectal Disease 2009; 11 (Suppl 2):49
Alvi A, Wood L, Davies R J
A selective policy ensures safe integration of laparoscopic colorectal resection into consultant practice after fellowship training.
European Society of Coloproctology Annual Meeting, Prague, Czech Republic. September 2009 Colorectal Disease 2009; 11 (Suppl 2):32
E D Courtney, M Brennan, G Noble-Jamieson, R Heuschkel, R J Davies
Laparoscopic adult colorectal surgeon and adolescents with inflammatory bowel disease: a safe combination?
European Society of Coloproctology Annual Meeting, Prague, Czech Republic. September 2009 Colorectal Disease 2009; 11 (Suppl 2):30
Shaw C, Elliott K, Wilkinson S, Goodwin K, Fearnhead NS, Miller R, Hall NR, Davies RJ.
How useful is a CT scan in the investigation of patients with iron deficiency anaemia?
Association of Coloproctology of Great Britain and Ireland Annual Meeting, Harrogate. June 2009 Colorectal Disease 2009;11 (Suppl 1):21
E D Courtney, M Brennan, G Noble-Jamieson, R Heuschkel, R J Davies
Surgery for adolescents with inflammatory bowel disease: results of a new tertiary service.
Association of Coloproctology of Great Britain and Ireland Annual East Anglia Chapter Meeting, Cambridge. May 2009
Shaw C, Elliott K, Wilkinson S, Goodwin K, Fearnhead NS, Miller R, Hall NR, Davies RJ.
How useful is a CT scan in the investigation of patients with iron deficiency anaemia?
Association of Coloproctology of Great Britain and Ireland Annual East Anglia Chapter Meeting, Cambridge. May 2009
Stabler A, Fearnhead N S, Davies R J, Tytherleigh M G, Miller R, Hall N R.
Anal Fistula Plug: The Cambridge experience with long-term follow-up.
Association of Coloproctology of Great Britain and Ireland Annual East Anglia Chapter Meeting, Cambridge. May 2009
Alvi A, Wood L, Davies R J.
A Selective Policy Ensures Safe And Efficient Integration Of Laparoscopic Colorectal Resection Into The Practice Of A Newly Appointed Consultant Surgeon. (Trainees Prize Winning Paper)
East Anglian Chapter Association of Coloproctology of Great Britain and Ireland Annual Meeting, Norwich. November 2008
Parsons B, Davies R J, Corr C, Durdey P, Sylvester P A, Virjee J, Callaway M.
How should we investigate lower gastrointestinal tract bleeding?
Association of Coloproctology of Great Britain and Ireland Annual Meeting, Gateshead. July 2006 Colorectal Disease 2006; 8 (Suppl 2): 40
Parsons B, Davies R J, Corr C, Durdey P, Sylvester P A, Virjee J, Callaway M.
How should we investigate lower gastrointestinal tract bleeding?
Association of Surgeons of Great Britain and Ireland Annual Meeting, Edinburgh. May 2006. British Journal of Surgery 2006; 93 (Suppl 1): 214
Chatrath P, Scott I S, Morris L S, Davies R J, Vowler S L, Laskey R A, Coleman N.
The role of surface brushings in the non-invasive detection of laryngeal dysplasia.
Annual Meeting of the American Academy of Otolaryngology, Los Angeles, USA. September 2005 Otolaryngology - Head and Neck Surgery 2005; 133 (Suppl 1): 147
Chatrath P, Scott I S, Odell E W, Morris L S, Davies R J, Vowler S L, Laskey R A, Coleman N.
A minimally invasive approach to the early detection of oral dysplasia.
Annual Meeting of the American Academy of Otolaryngology, Los Angeles, USA. September 2005 Otolaryngology - Head and Neck Surgery 2005; 133 (Suppl 1): 97
Harris M E, Davies R J, Brown S, Jones S M, Eyers P S, Chester J F.
Rationing of referrals for varicose veins: its effect on surgical workload.
Association of Surgeons of Great Britain and Ireland Annual Meeting, Glasgow. April 2005. British Journal of Surgery 2005; 92 (Suppl 1): 9
Barros D'Sa I, Davies R J, Silavant M, Fowler A L, Lucarotti M E, Cook T A.
Full pre-operative imaging of colorectal cancer leads to a delay in initiation of treatment: resource implications for the 28-day target.
Association of Coloproctology of Great Britain and Ireland Annual Meeting, Birmingham. June 2004 Colorectal Disease 2004; 6 (Suppl 1): 53
Barros D'Sa I, Davies R J, Silavant M, Fowler A L, Lucarotti M E, Cook T A.
Full pre-operative imaging of colorectal cancer leads to a delay in initiation of treatment: resource implications for the 28-day target.
Association of Surgeons of Great Britain and Ireland Annual Meeting, Harrogate. April 2004. British Journal of Surgery 2004; 91 (Suppl 1): 87
Pryce Lewis J, Davies R J, Welbourn R.
Training in laparoscopic surgery in the south western deanery: results of a regional survey.
Association of Endoscopic Surgeons of Great Britain and Ireland Annual Meeting, Manchester. May 2003
Davies R J, Collins C D, Eyre-Brook I, Vickery C J, Welbourn R.
A prospective observational study over three years to assess the impact of the two-week target on emergency admissions with colorectal cancer.
Association of Surgeons of Great Britain and Ireland Annual Meeting, Manchester. May 2003 British Journal of Surgery 2003; 90 (Suppl 1): 132
Davies R J, Freeman A, Morris L S, Scott I S, Bird K, Brown J, Bailey N, Bandaletova T, Bingham S, Miller R, Coleman N.
A novel method for detecting colorectal cancer in stool.
Pathological Society of Great Britain and Ireland Annual Meeting, Dublin. July 2002
Proceedings of the Pathological Society of Great Britain and Ireland 2002; 65
Davies R J, Longman R J, Ewings P, Sheffield J, Kennedy R.
Comparison of laparoscopic versus open resection of colorectal cancer.
Association of Coloproctology of Great Britain and Ireland Annual Meeting, Harrogate. June 2001 Colorectal Disease 2001; 3 (Suppl 1): 63
Davies R J, Welbourn R, Collins C, Kennedy R, Royle C.
A prospective study to assess the implementation of a fast-track system to meet the two-week target for colorectal cancer.
British Society of Gastroenterology Annual Meeting, Glasgow. March 2001 Gut 2001; 48 (Suppl 1): A53
Davies R J, Ewings P, Sheffield J, Kennedy R.
Comparison of laparoscopic versus open resection of colorectal cancer.
101st Annual Congress of the Japan Surgical Society, Sendai, Japan. March 2001 Journal of Japan Surgical Society 2001; 102: 489
Parvaiz A, Davies R J, Williams S, Griffiths D, Gajraj H.
Meeting the two-week wait for breast cancer in a district general hospital.
British Association of Surgical Oncology (BASO) Annual Meeting, London. November 2000. European Journal of Surgical Oncology 2000; 26: 867
Sylvester P, Davies R J, Wong N, Warren B, Corfield A, Thomas M G, Durdey P
Expression of neoplasia-associated mucin carbohydrates within the ileoanal reservoir.
Association of Coloproctology of Great Britain and Ireland Annual Meeting, Southport. June 1999. Colorectal Disease 1999; 1 (Suppl): 49
Longman R J, Stebbing J F, Davies R J, Thomas M G.
Routine intra-operative hepatic ultrasound in patients with colorectal cancer.
Digestive Diseases Week, American Gastroenterology Association, Orlando, Florida, USA, May 1999 Gastroenterology 1999; 116: A456
Longman R J, Stebbing J F, Davies R J, Thomas M G.
Routine intra-operative hepatic ultrasound in patients with colorectal cancer.
Association of Surgeons of Great Britain and Ireland Annual Meeting, Brighton. May 1999. British Journal of Surgery 1999; 86 (Suppl): 101
Davies R J, Longman R J, Crowther M, Durdey P, Thomas M G.
An audit of the pre-operative assessment of colorectal cancer patients: are we achieving the Guidelines?
Association of Coloproctology of Great Britain and Ireland Annual Meeting, Jersey. July 1998.
Surgical Innovation (2011 to present)
Updates in Surgery (2011 to present)
British Journal of Surgery (2010 to present)
Colorectal Disease (2010 to present)
Diseases of the Colon and Rectum (2008 to present)
The Open Colorectal Cancer Journal (Editorial Board member 2008 to present)
Expert Review of Molecular Diagnostics (2008 to present)
European Journal of Gastroenterology and Hepatology (2007 to present)
Nature Clinical Practice Oncology (2005 to present)
Gut (2002 to present)
REFEREE FOR RESEARCH GRANT AWARDING ORGANISATIONS
The Netherlands Organisation For Health Research and Development (2005 to present)
Association of Coloproctology of Great Britain and Ireland
American Society of Colon and Rectal Surgeons
Association of Laparoscopic Surgeons of Great Britain and Ireland
European Society of Coloproctology
European Association for Endoscopic Surgery
Society of Academic and Research Surgery
Fellow of The Royal Society of Medicine
My main interests have always been sporting, particularly rugby union. I won my Cambridge Blue in 1994, playing scrum-half for the winning Cambridge University side in the Varsity Match at Twickenham. I made over 50 appearances for The Blues, and won LX Club Colours and Under 21 Colours, captaining all sides including The Blues. At school, I represented England Schools 18 Group.
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